Inhibitors of ccr9 activity

Details Inhibitors of ccr9 activity Inhibitors of ccr9 activity

C - Chemistry, Metallurgy

07

D

C07D 333/34 (2006.01) A61K 31/381 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2632438

Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1- 4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.

La présente invention concerne des composés de formule (I) dans laquelle l'un de R1 ou de R2 représente un thiényle substitué par un halogène et l'autre de R1 ou de R2 représente un phényle substitué. Les substituants sont tels que définis dans les revendications de la présente invention, sous réserve que le groupe phényle soit substitué par au moins un groupe cyano, carboxy ou (C1-4)alkyloxycarbonyle. Ces composés constituent des inhibiteurs de l'activité du récepteur CCR9 et sont utilisés dans le cadre d'une thérapie.

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