Inhibitors of cell proliferation, their preparation and use

Details Inhibitors of cell proliferation, their preparation and use Inhibitors of cell proliferation, their preparation and use

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2142185

Disclosed is the characterization and purification of DNA encoding numerous polypeptides factors useful for the inhibi- tion of cell (particularly, Schwann cell) proliferation. These factors are useful for the treatment of neural tumors. Also disclosed are the DNA sequences encoding novel polypeptides which may have use as agents which inhibit cell proliferation. Methods for the synthesis, purification, and testing of both known and novel polypeptides for their use as therapeutic and diagnostic aids in the treatment of diseases are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes. Such probes have diagnostic and therapeutic use in diseases involving neural and glial cells.

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