C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/10 (2006.01) A61K 31/473 (2006.01) A61K 31/5377 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2612841
The instant invention provides for compounds which comprise benzoisoquinolinones and aza derivatives that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
La présente invention concerne des composés comprenant des benzoisoquinolinones et des dérivés aza inhibant l'activité de CHK1. L'invention concerne également des compositions comprenant ces composés inhibiteurs ainsi que des méthodes destinées à inhiber l'activité de CHK1 par administration du composé à un patient nécessitant un traitement anticancéreux.
Arrington Kenneth L.
Dudkin Vadim Y.
Fraley Mark E.
Garbaccio Robert M.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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