Inhibitors of checkpoint kinases

Details Inhibitors of checkpoint kinases Inhibitors of checkpoint kinases

C - Chemistry, Metallurgy

07

D

C07D 235/06 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2594657

The instant invention provides for compounds which comprise substituted indolyl indazoles that inhibit CHK1 activity. The instant compounds provide a novel mechanism of action with unexpected advantageous properties; such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.

L'invention se rapporte à des composés contenant des indazoles d'indolyl substitués qui inhibent l'activité de CHK1. Ces composés fournissent un nouveau mécanisme d'action présentant des propriétés avantageuses inédites ; ces propriétés avantageuses inédites comprenant une meilleure puissance/solubilité cellulaire, une meilleure sélectivité, des propriétés pharmacocinétiques améliorées, un manque d'activité hors cible etc. Cette invention se rapporte aussi à des compositions contenant ces composés inhibiteurs et à des procédés d'inhibition de l'activité de CHK1 par administration du composé à un patient qui doit recevoir un traitement contre le cancer.

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