C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4745 (2006.01) C07D 471/14 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01)
Patent
CA 2590332
The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
La présente invention concerne des composés qui comprennent des pyrazoles fusionnés inhibant l'activité de CHK1. L'invention concerne également des compositions comprenant lesdits composés inhibiteurs ainsi que des méthodes d'inhibition de l'activité de CHK1 par administration du composé à un patient nécessitant un traitement contre le cancer.
Brnardic Edward J.
Fraley Mark E.
Garbaccio Robert M.
Steen Justin T.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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