Inhibitors of checkpoint kinases (wee1 and chk1)

Details Inhibitors of checkpoint kinases (wee1 and chk1) Inhibitors of checkpoint kinases (wee1 and chk1)

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 307/00 (2006.01) C07D 333/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2483496

This invention relates to pyrrolocarbazole derivatives according formula (I) wherein R1, R2, r7, R8 R9, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1.

Cette invention porte sur des dérivés pyrrolocarbazole représentés par la formule (I) dans laquelle R?1¿, R?2¿, R?7¿, R?8¿, R?9¿, X et Y sont tels que définis dans la description, lesquels dérivés inhibent de manière spécifique l'une des deux, voire les deux checkpoint kinases Wee1 et Chk1.

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