Inhibitors of cholesterol esterase

Details Inhibitors of cholesterol esterase Inhibitors of cholesterol esterase

C - Chemistry, Metallurgy

07

D

C07D 307/20 (2006.01) C07D 307/88 (2006.01) C07D 309/38 (2006.01) C07D 311/76 (2006.01) C07D 315/00 (2006.01)

Patent

CA 2284525

The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.

Cette invention a trait à de nouvelles lactones haloénol efficaces comme inhibiteurs du site actif de la cholestérol estérase. En inhibant la cholestérol estérase, les inhibiteurs de l'invention offrent de nouvelles perspectives en matière de traitement de l'hypercholesterolémie dans la mesure où ils limitent la biodisponibilité du cholestérol alimentaire.

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