Inhibitors of complement activation

Details Inhibitors of complement activation Inhibitors of complement activation

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 37/02 (2006.01) C07H 21/00 (2006.01) C07K 7/00 (2006.01) C07K 16/40 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2321140

The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, (Fab')2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166- 32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, VA 20110-2209, under Accession Number HB-12476.

La présente invention concerne des inhibiteurs du facteur D, qui se lient au facteur D et bloquent son activité fonctionnelle relative à l'activation du complément. Ces inhibiteurs comprennent des molécules d'anticorps, ainsi que des homologues, analogues et des formes modifiées ou dérivées de ceux-ci, comprenant des fragments d'immunoglobuline tels que Fab, (Fab')¿2? et Fv, de petites molécules, notamment des peptides, des oligonucléotides, des peptidomimétiques et des composés organiques. On a par ailleurs produit et appelé 166-32 un anticorps monoclonal se liant au facteur D et bloquant sa capacité à activer le complément. L'hybridome produisant cet anticorps a été déposé à la " American Type Culture Collection", 10801 University Blvd., Manassas, Va 20110-2209, sous le numéro d'entrée HB-12476.

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