Inhibitors of copper-containing amine oxidases

Details Inhibitors of copper-containing amine oxidases Inhibitors of copper-containing amine oxidases

C - Chemistry, Metallurgy

07

D

C07D 273/04 (2006.01) A61K 31/14 (2006.01) A61K 31/15 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/472 (2006.01) A61P 1/04 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2414807

The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R1 to R8 and X are as defined herein.

L'invention concerne des composés hydrazino agissant en tant qu'inhibiteurs d'amines oxydases contenant du cuivre, généralement appelées amines oxydases sensibles au semicarbazide (SSAO), notamment les SSAO humaines telles que la protéine d'adhérence vasculaire 1 (VAP-1). Ces inhibiteurs de SSAO possèdent une utilité thérapeutique en tant que médicaments destinés au traitement de pathologies et maladies comprenant, sans y être limitées, un certain nombre d'états et maladies inflammatoires (y compris des pathologies inflammatoires chroniques telles que l'arthrite chronique, les infections inflammatoires du tube digestif, et les dermatoses chroniques), des maladies associées au métabolisme des hydrates de carbone et aux aberrations de la différentiation ou fonction adipocytaire et de la fonction des cellules de la fibre lisse, et des maladies vasculaires. Ces composés possèdent les formules générales (I) et (II) dans lesquelles R?1¿ à R?8¿ possèdent les notations données dans la description; l'invention concerne encore un solvate, hydrate ou sel de ces composés, acceptable sur le plan pharmacologique.

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