C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/165 (2006.01) A61K 38/16 (2006.01) A61K 39/215 (2006.01) A61P 31/14 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2522329
The present invention relates to inhibitors of coronaviruses including severe acute respiratory syndrome (SARS); methods of identifying inhibitors of coronaviruses; methods and compositions useful for therapy (treatment, or prevention) of coronavirus infections. The coronavirus inhibitors target different regions of the coronavirus Spike protein to inhibit coronavirus replication. In particular embodiments, the inhibitors include Five-Helix proteins, HR2 peptides, HR1 peptides, HR1 chimeric peptides. The present invention also features retro-inverso analogue of the coronavirus inhibitors, coronavirus inhibitors containing one or more tryptophan analogs, and / or one or more lactam bridges.
La présente invention concerne des inhibiteurs de coronavirus notamment du syndrome respiratoire aigu sévère (SRAS); des méthodes d'identification d'inhibiteurs de coronavirus ; des méthodes et des compositions utiles dans la thérapie (le traitement ou la prévention) d'infections à coronavirus. Les inhibiteurs de coronavirus ciblent différentes régions de la protéine Spike de coronavirus afin d'inhiber la réplication de coronavirus. Dans des modes de réalisation particuliers, les inhibiteurs comprennent des protéines Cinq-Helix, des peptides HR2, des peptides HR1, des peptides chimères HR1. La présente invention concerne également un analogue rétro-inverso des inhibiteurs de coronavirus, des inhibiteurs de coronavirus contenant un ou plusieurs analogues de tryptophane et/ou un ou plusieurs ponts lactame.
Eckert Debra
Freidinger Roger M.
Garsky Victor M.
Geleziunas Romas
Kim Peter S.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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