Inhibitors of cruzipain and other cysteine proteases

Details Inhibitors of cruzipain and other cysteine proteases Inhibitors of cruzipain and other cysteine proteases

C - Chemistry, Metallurgy

07

D

C07D 307/93 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/5377 (2006.01) A61P 33/02 (2006.01) C07D 307/935 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2434068

Compounds of general formula (I): wherein R1, Y, (X)0, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therpeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.

L'invention concerne des composés de formule générale (I). R?1¿, Y, (X)¿o?, (W)¿n?, (V)¿m?, Z et U sont, tels que définis dans le descriptif, des inhibiteurs de la cruzipaine et d'autres inhibiteurs de la cystéine protéase. Ils sont utilisés comme agents thérapeutiques, par exemple dans la maladie de Chagas, ou pour valider des composés cibles thérapeutiques.

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