Inhibitors of cruzipain and other cysteine proteases

Details Inhibitors of cruzipain and other cysteine proteases Inhibitors of cruzipain and other cysteine proteases

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4355 (2006.01) A61P 33/02 (2006.01)

Patent

CA 2436462

Compounds of general formula (I) or general formula (II) wherein R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.

Cette invention concerne des composés représentés par la formule générale (I) ou (II) dans lesquelles R?1¿, P¿1?, P¿2?, Q, Y, (X)¿o?, (W)¿n?, (V)¿m?, Z et U sont comme définis dans le descriptif. Ces composés, qui sont des inhibiteurs de la cruzipaïne et autres cystéines protéases, sont utiles comme agents thérapeutiques, par exemple pour la maladie de Chagas, ou pour valider des composés thérapeutiques cibles.

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