Inhibitors of cyclin-dependent kinases and their use

Details Inhibitors of cyclin-dependent kinases and their use Inhibitors of cyclin-dependent kinases and their use

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/353 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2492130

The present invention relates to novel compounds for the inhibition of cyclin- dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of such compounds, methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, use of such compounds in the treatment and prophylaxis of diseases, and to the use of the compounds in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing such compounds either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing such compounds of either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

L'invention concerne de nouveaux composés permettant l'inhibition de kinases dépendantes des cyclines et, plus particulièrement, des dérivés chroménone de formule (Ia) dans laquelle R1, R2, R3, R4, R5, R6, R7 et A ont les significations indiquées dans les revendications. L'invention concerne également des procédés de préparation de tels composé, des procédés d'inhibition de kinases dépendantes des cyclines, et d'inhibition de la prolifération cellulaire, ainsi que l'utilisation desdits composés dans le traitement et la prophylaxie de maladies, et l'utilisation des composés dans la préparation de médicaments à appliquer dans de telles maladies. L'invention concerne en outre des compositions contenant de tels composés, soit seuls, soit en combinaison avec un autre agent actif, en mélange ou en association avec un support inerte, en particulier des compositions pharmaceutiques contenant de tels composés soit seuls, soit en combinaison avec un autre agent actif, conjointement avec des substances supports pharmaceutiquement acceptables et des substances auxiliaires.

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