Inhibitors of cyclin dependent kinases as anti-cancer agent

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2440228

The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferation disorders such as cancer, leukaemia, psoriasis and the like.

L'invention concerne des 4-hétéroaryle-pyrimidines 2-substituées, leur préparation, des compositions pharmaceutiques les contenant, leur utilisation en tant qu'inhibiteurs de kinases dépendantes des cyclines et donc leur utilisation dans le traitement de troubles prolifératifs tels que le cancer, la leucémie, le psoriasis et autres affections similaires.

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