C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/416 (2006.01) A61K 31/519 (2006.01) A61K 31/675 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 231/54 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 519/00 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2551640
The invention pertains to novel cyclin dependent kinase inhibitors (cdks) of formula (I) wherein the substituents are as defined in the claims and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell- cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
L'invention se rapporte à des nouveaux inhibiteurs des kinases dépendantes des cyclines (cdks), représentés par la formule (I), dans laquelle les substituants sont tels que définis dans les revendications, et plus spécifiquement mais non exclusivement, à des inhibiteurs des complexes cdk/cycline. Les inhibiteurs décrits sont capables d'inhiber le mécanisme du cycle cellulaire et peuvent par conséquent servir à moduler la progression du cycle cellulaire, voire à réguler la croissance et la différenciation cellulaires. Des composés de ce type pourraient être utiles pour le traitement de sujets présentant des troubles associés à une prolifération cellulaire excessive.
Bockovich Nicholas
Huang Jianxing
Kluge Arthur F.
Murthi Krishna K.
Oalmann Chris
Agennix Usa Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gpc Biotech Inc.
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