C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/416 (2006.01) A61K 31/519 (2006.01) A61K 31/675 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 231/00 (2006.01) C07D 231/54 (2006.01) C07D 239/00 (2006.01) C07D 403/12 (2006.01) C07F 9/6503 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2463571
The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell- cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
L'invention concerne des nouveaux inhibiteurs de kinases dépendantes des cyclines (Cdk). Plus particulièrement, mais pas exclusivement, elle se rapporte à des inhibiteurs de complexes Cdk/cycline. Les inhibiteurs de l'invention sont capables d'inhiber le mécanisme du cycle cellulaire. Par conséquent, ils peuvent être utiles dans la modulation de la progression du cycle cellulaire, et, finalement, dans la régulation de la croissance cellulaire et de la différenciation cellulaire. Ces composés seraient utiles pour traiter des sujets présentant des troubles associés à une multiplication cellulaire excessive.
Becker Frank
Bockovich Nicholas
Kluge Arthur F.
Murthi Krishna K.
Oalmann Chris
Becker Frank
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gpc Biotech Inc.
Gpc Biotech Ag
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