C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/416 (2006.01) A61K 31/519 (2006.01) A61K 31/675 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 231/54 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 519/00 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2521854
The invention pertains to novel cyclin dependent kinase inhibitors (cdks) of formulae (II) and (I) wherein the substituents are as defined in the claims and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
L'invention se rapporte à de nouveaux inhibiteurs des kinases dépendant des cyclines (CDK) et plus particulièrement, mais non exclusivement, à des inhibiteurs de complexes CDK/cyclines. Les inhibiteurs de la présente invention permettent d'inhiber le mécanisme du cycle cellulaire et ils peuvent par conséquent être utilisés pour moduler la progression du cycle cellulaire, dans le but d'une régulation de la croissance cellulaire et de la différenciation cellulaire. Ces composés peuvent être utiles pour traiter des sujets présentant des troubles associés à une prolifération cellulaire excessive.
Bockovich Nicholas
Huang Jianxing
Kluge Arthur F.
Murthi Krishna K.
Oalmann Chris
Agennix Usa Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gpc Biotech Inc.
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