Inhibitors of cytosolic phospholipase a2

Details Inhibitors of cytosolic phospholipase a2 Inhibitors of cytosolic phospholipase a2

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 31/404 (2006.01) A61P 11/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2607857

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA.alpha.). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

La présente invention a trait à des inhibiteurs chimiques de l'activité de diverses enzymes phospholipase, notamment des enzymes phospholipase A2 cytosolique (cPLA2), plus particulièrement comprenant des inhibiteurs d'enzymes alpha phospholipase A2 cytosolique (cPLAa). Dans certains modes de réalisation, les inhibiteurs sont de formule I, dans laquelle les variables constitutifs sont tels que définis dans la description.

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