Inhibitors of d-amino acid oxidase

Details Inhibitors of d-amino acid oxidase Inhibitors of d-amino acid oxidase

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/403 (2006.01) A61P 25/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2676432

The present invention provides novel inhibitors of the enzyme D- amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/ or conditions, wherein modulation of D- serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatry diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.

La présente invention concerne de nouveaux inhibiteurs de l'enzyme D-amino acide oxydase. Les composés de l'invention sont utiles pour le traitement ou la prévention de maladies et/ou d'affection, où la modulation de niveaux de D-sérine et/ou ces produits oxydatifs est efficace pour l'amélioration des symptômes. L'invention concerne en outre des procédés d'amélioration de l'apprentissage, de la mémoire et/ou de la commission. A titre d'exemple, l'invention propose des procédés pour le traitement ou la prévention de la perte de mémoire et/ou de la cognition associés à des maladies neurodégénératives, telles que la maladie d'Alzheimer. L'invention propose en outre des procédés pour la prévention de la perte de fonction neuronale caractéristique de maladies neurodégénératives. De plus, des procédés sont prévus pour le traitement et la prévention de maladies neuropsychiatriques (par exemple, schizophrénie) et pour le traitement ou la prévention de la douleur et de l'ataxie.

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