C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/44 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2743723
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below.
La présente invention concerne de nouveaux composés hétérocycliques en tant qu'inhibiteurs de diacylglycérol acyltransférase (« DGAT »), des compositions pharmaceutiques comprenant les composés hétérocycliques et l'utilisation des composés pour traiter ou prévenir une maladie cardiovasculaire, un trouble métabolique, l'obésité ou un trouble associé à l'obésité, le diabète, la dyslipidémie, une complication diabétique, une tolérance au glucose altérée ou une glycémie à jeun altérée. Un composé illustratif de l'invention est décrit ci-dessous.
Aslanian Robert G.
Cao Jianhua
Caplen Mary Ann
Kim David Won-Shik
Kim Hyunjin
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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