Inhibitors of dipeptidyl peptidase iv

Details Inhibitors of dipeptidyl peptidase iv Inhibitors of dipeptidyl peptidase iv

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/425 (2006.01) A61P 5/50 (2006.01) C07D 207/16 (2006.01) C07D 213/82 (2006.01) C07D 241/24 (2006.01) C07D 277/04 (2006.01) C07D 277/06 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2407663

Compounds according to general formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is O, S or CH2, X3 is NR5 or a carbonyl or thiocarbonyl group and R4 is R6R7N, R8(CH2)qOC(=O), R8(CH2)qOC(=S), R6R7NC(=O), R6R7NC(=S); R8(CH2)qC(=O), R8(CH2)qC(=S) or R8(CH2)qSO2, m is 1-3 and n is 0-4 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of,inter alia, type 2 diabetes.

L'invention concerne de nouveaux composés selon la formule générale (1) dans laquelle R?1¿ désigne H ou CN, X?1¿ désigne S,O,SO¿2? ou CH¿2?, X?2¿ désigne O,S ou CH¿2?, X?3¿ désigne NR?5¿ ou un groupe carbonyle ou thiocarbonyle et R?4¿ désigne R?6¿R?7¿N, R?8¿(CH¿2?)¿q?OC(=O), R?8¿(CH¿2?)¿q?OC(=S), R?6¿R?7¿NC(=O), R?6¿R?7¿NC(=S) ; R?8¿(CH¿2?)¿q?C(=O), R?8¿(CH¿2?)¿q?C(=S) ou R?8¿(CH¿2?)¿q?SO¿2?, m vaut entre 1 et 3 et n vaut entre 0 et 4. Ces composés sont des inhibiteurs de la dipeptidyl peptidase IV. Des compositions pharmaceutiques de ces composés ou leurs sels pharmaceutiquement acceptables s'utilisent dans le traitement, entre autres, de diabètes de type 2.

Affiliated with

Also associated with

Rating

Inhibitors of dipeptidyl peptidase iv does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of dipeptidyl peptidase iv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of dipeptidyl peptidase iv will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1498122