Inhibitors of dipeptidyl peptidase iv

Details Inhibitors of dipeptidyl peptidase iv Inhibitors of dipeptidyl peptidase iv

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2407662

Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1-5 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of, inter alia, type 2 diabetes.

L'invention concerne de nouveaux composés de formule générale (1), dans laquelle R?1¿ représente H ou CN, X?1¿ représente S, O, SO¿2? ou CH¿2?, X?2¿ représente CO, CH¿2? ou une liaison covalente, Het représente un hétérocycle contenant de l'azote et n est compris entre 1 et 5, lesdits composés étant des inhibiteurs de la dipeptidyl peptidase IV. Cette invention concerne aussi des compositions pharmaceutiques renfermant ces composés ou des sels correspondants acceptables sur le plan pharmaceutique, utilisés dans le traitement notamment de diabètes de type 2.

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