Inhibitors of e1 activating enzyme

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/7064 (2006.01) A61K 31/7076 (2006.01) A61P 35/00 (2006.01) C07D 473/34 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2639924

This invention relates to compounds of formula (I) that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

La présente invention concerne des composés inhibiteurs des enzymes d'activation E1 , des compositions pharmaceutiques comportant les composés, et des procédés d'utilisation des composés. Les composés sont utiles pour le traitement de troubles, notamment des troubles de la prolifération cellulaire, comprenant des cancers, des troubles inflammatoires et neurodégénératifs; et d'inflammation associée à une infection et de la cachexie.

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