Inhibitors of e1 activating enzymes

Details Inhibitors of e1 activating enzymes Inhibitors of e1 activating enzymes

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2596424

This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

Cette invention concerne des composés inhibant les enzymes d'activation E1, des compositions pharmaceutiques comprenant de tels composés ainsi que des méthodes permettant d'utiliser ces composés. Les composés décrits dans cette invention sont utiles pour traiter des troubles, plus particulièrement, des troubles de prolifération cellulaires, parmi lesquels, les cancers, des troubles inflammatoires et neurodégénératifs, ainsi qu'une inflammation associée à une infection et à la maigreur.

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