Inhibitors of extracellular hsp90

Details Inhibitors of extracellular hsp90 Inhibitors of extracellular hsp90

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/00 (2006.01) A61K 31/335 (2006.01) A61K 31/37 (2006.01) A61K 31/52 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/48 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/554 (2006.01)

Patent

CA 2518944

The present invention describes the inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.

La présente invention a trait à des inhibiteurs de protéines de choc thermique 90 (Hsp90) extracellulaires. L'inhibition des Hsp90 entraîne la réduction du caractère envahissant de cellules tumorales. L'invention a également trait à l'utilisation de molécules inhibitrices de la fonction des Hsp90 extracellulaires pour la fabrication d'un médicament pour le traitement ou la prévention d'invasion et/ou de potentiel métastatique de cellules cancéreuses.

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