Inhibitors of factor xa

Details Inhibitors of factor xa Inhibitors of factor xa

C - Chemistry, Metallurgy

07

C

C07C 311/46 (2006.01) A61K 31/18 (2006.01) A61K 31/277 (2006.01) A61K 31/501 (2006.01) A61P 7/02 (2006.01) C07C 311/16 (2006.01) C07D 213/40 (2006.01) C07D 213/74 (2006.01) C07D 217/22 (2006.01) C07D 295/192 (2006.01) C07D 295/26 (2006.01) C07D 307/52 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2374793

Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

L'invention concerne de nouveaux composés, leurs sels ainsi que des compositions relatives à ceux-ci présentant une activité contre le facteur Xa mammifère. Les composés sont utiles (in vitro) ou (in vivo) dans la prévention ou dans le traitement de dysfonctionnements de la coagulation.

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