Inhibitors of factor xa

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 311/46 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) A61P 7/02 (2006.01) C07C 257/18 (2006.01) C07C 311/51 (2006.01) C07D 213/58 (2006.01) C07D 217/22 (2006.01) C07D 231/12 (2006.01) C07D 231/56 (2006.01) C07D 239/94 (2006.01) C07D 307/54 (2006.01) C07D 401/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2361428

Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammalian Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

L'invention porte sur de nouveaux composés leurs sels et des compositions associées s'avérant actifs contre le facteur Xa des mammifères et agissant in vivo et in vitro pour prévenir ou traiter les troubles de la coagulation.

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