Inhibitors of factor xa and other serine proteases involved...

Details Inhibitors of factor xa and other serine proteases involved... Inhibitors of factor xa and other serine proteases involved...

C - Chemistry, Metallurgy

07

C

C07C 317/32 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) C07C 311/46 (2006.01) C07D 207/16 (2006.01) C07D 211/76 (2006.01) C07D 213/75 (2006.01) C07D 309/14 (2006.01) C07D 335/02 (2006.01)

Patent

CA 2497003

This invention discloses amino acid derivatives which display inhibitory effects on the serine protease factor Xa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, methods for the preparation of the compounds, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.

L'invention concerne des dérivés d'acides aminés ayant des effets inhibiteurs sur le facteur Xa de sérine protéase, y compris les sels pharmaceutiquement acceptables de ces composés, des compositions pharmaceutiquement acceptables renfermant les composés considérés ou leur sels, des procédés relatifs à l'élaboration de ces composés, et des procédés relatifs à leur utilisation comme agents thérapeutiques pour le traitement ou la prévention d'états pathologiques chez des mammifères caractérisés par une thrombose anormale.

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