Inhibitors of factor xii activation and applications thereof

Details Inhibitors of factor xii activation and applications thereof Inhibitors of factor xii activation and applications thereof

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082643

2082643 9117258 PCTABS00008 Compositions and methods for prophylactically or therapeutically treating sepsis consisting of an inhibitor of Factor XII activation wherein the inhibitor is preferably antibody and has the exemplary properties: binds to and inactivates Factor XII in plasma; substantially inhibits the enzymatic activity of Factor XIIa; and is substantially unreactive with Factor XII-C1 complexes.

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