A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) C07D 213/22 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 405/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2276150
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
La présente invention concerne des composés qui inhibent la farnésyl-protéine transférase (FTase). L'invention concerne également la farnésylation de la protéine oncogène Ras. L'invention concerne enfin des compositions chimiothérapiques qui renferment les composés de la présente invention, les procédés permettant d'inhiber la farnésyl-protéine transférase, et la farnésylation de la protéine oncogène Ras
Anthony Neville J.
Bell Ian M.
Desolms S. Jane
Gomez Robert P.
Graham Samuel L.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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