C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/64 (2006.01) A61K 31/33 (2006.01) A61K 31/415 (2006.01) C07D 207/337 (2006.01) C07D 213/57 (2006.01) C07D 231/12 (2006.01) C07D 235/06 (2006.01) C07D 239/26 (2006.01) C07D 271/02 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 409/00 (2006.01) C07D 417/00 (2006.01)
Patent
CA 2243272
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Composés qui inhibent la farnésyl-protéine transférase (Ttase) et la farnésylation de la protéine oncogène Ras. La présente invention concerne en outre des compositions chimiothérapeutiques contenant lesdits composés et des procédés permettant d'inhiber la farnésyl-protéine transférase et la farnésylation de la protéine oncogène Ras.
Dinsmore Christopher J.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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