C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/10 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/55 (2006.01) C07D 267/22 (2006.01) C07D 281/18 (2006.01) C07D 291/00 (2006.01) C07D 337/16 (2006.01) C07D 487/00 (2006.01) C07D 487/08 (2006.01) C07D 491/00 (2006.01) C07D 498/08 (2006.01) C07D 513/00 (2006.01)
Patent
CA 2306312
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (FTase) et la farnésylation de la protéine Ras oncogène. L'invention concerne en outre des compositions chimiothérapeutiques contenant les composés de l'invention et des procédés pour inhiber la farnésyl-protéine transférase et la farnésylation de la protéine Ras oncogène.
Bergman Jeffrey M.
Dinsmore Christopher J.
Graham Samuel L.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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