Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 211/36 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) A61K 31/4545 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/32 (2006.01) C07D 211/34 (2006.01) C07D 211/48 (2006.01) C07D 211/54 (2006.01) C07D 211/64 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2198726

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein <u>Ras</u>. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.

L'invention concerne des composés qui inhibent la farnésyle-protéine transférase (FTase) et la farnésylation de la protéine encogène <u>Ras</u>. L'invention concerne également des compositions contenant lesdits composés, utilisées en chimiothérapie, ainsi que des procédés d'inhibition de la farnésyle-protéine transférase et de traitement du cancer.

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