Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2079253

115/MRD75 18541 TITLE OF THE INVENTION INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ABSTRACT OF THE DISCLOSURE The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemothera peutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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