C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/02 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) C07D 235/30 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2312366
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemoterapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (Ftase) et la farnélysation de la protéine Ras oncogène. L'invention concerne également des composés chimiothérapeutiques contenant les composés de l'invention et des procédés d'inhibition de la farnésyl-protéine transférase et la farnélysation de la protéine Ras oncogène.
Ciccarone Terrence M.
Halczenko Wasyl
Hutchinson John H.
Lumma William C. Jr.
Stokker Gerald E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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