Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

C

C07C 323/25 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/365 (2006.01) C07C 323/56 (2006.01) C07C 323/59 (2006.01) C07D 307/33 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2147241

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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