Inhibitors of farnesyl protein transferase

C - Chemistry – Metallurgy – 12 – P

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C12P 17/04 (2006.01) A61K 31/19 (2006.01) A61K 31/225 (2006.01) A61K 31/365 (2006.01) C07C 57/13 (2006.01) C07C 69/52 (2006.01) C07C 69/602 (2006.01) C12N 1/14 (2006.01) C12P 7/44 (2006.01) C12P 7/64 (2006.01)

Patent

CA 2084795

131/MRD84 18611 TITLE OF THE INVENTION INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ABSTRACT OF THE INVENTION This invention relates to pharmaceutical compounds of structural formula (I): Image I and compositions and methods of treatment utilizing these compounds to inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras.

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