Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

12

N

C12N 1/14 (2006.01) A61K 31/35 (2006.01) C07D 493/04 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2227369

The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

L'invention concerne des composés non peptidiques qui inhibent la farnésyl protéine-transférase (FPTase) et la farnésylation de la protéine oncogène ras. Elle porte aussi sur le procédé de préparation d'un composé selon l'invention par mise en culture de Phoma sp, ainsi que sur des compositions chimiothérapeutiques contenant lesdits composés et des procédés pour inhiber la farnésyl protéine-transférase et la farnésylation de la protéine oncogène Ras.

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