Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/33 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 237/26 (2006.01) C07D 239/70 (2006.01) C07D 241/36 (2006.01) C07D 243/12 (2006.01) C07D 245/04 (2006.01) C07D 249/16 (2006.01) C07D 251/72 (2006.01) C07D 253/08 (2006.01) C07D 257/10 (2006.01) C07D 261/20 (2006.01) C07D 263/52 (2006.01) C07D 265/02 (2006.01) C07D 265/12 (2006.01) C07D 265/28 (2006.01) C07D 271/12 (2006.01) C07D 273/02

Patent

CA 2304473

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of formulas (I), (II), their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof inhibit farnesyl protein transferase which is an enzyme involved in ras oncogene expression.

Inhibition de la transférase farnésyle qui est une enzyme impliquée dans l'expression de l'oncogène ras, cette inhibition s'effectuant à l'aide des composés ayant les formules (I) et (II), leurs énantiomères, diastéréomères et leurs sels, promédicaments et solvates pharmaceutiquement acceptables qui inhibent la transférase farnésyle protéine, laquelle est une enzyme impliquée dans l'expression de l'oncogène ras.

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