Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

A - Human Necessities

01

N

A01N 43/40 (2006.01) A01N 43/54 (2006.01) A01N 43/58 (2006.01) C07D 401/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2276081

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

La présente invention concerne des composés qui inhibent la farnésyl-protéine transférase (FTase), et la farnésylation de la protéine oncogène Ras. L'invention concerne également des compositions chimiothérapiques qui renferment les composés de la présente invention, les procédés permettant d'inhiber la farnésyl-protéine transférase, et la farnésylation de la protéine oncogène Ras.

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