Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

C

C07C 323/25 (2006.01) A61K 31/13 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/325 (2006.01) A61K 31/40 (2006.01) C07C 321/10 (2006.01) C07C 323/60 (2006.01) C07D 209/08 (2006.01) C07D 209/46 (2006.01) C07D 217/14 (2006.01) C07D 223/16 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2216526

The present invention comprises peptidomimetic compounds which comprise a suitably aniline and aminoalkylbenzene moieties. The instant compounds inhibit the farnesyl-protein transferase enzyme and the farnesylation of certain proteins. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl- protein transferase and the farnesylation of the oncogene protein Ras.

La présente invention concerne des composés peptidomimétiques comprenant une aniline appropriée et des fractions d'aminoalkylbenzène. Les composés instantanés inhibent la farnésyl-protéine transférase et la farnélysation de certaines protéines. L'invention concerne en outre des compositions chimiques thérapeutiques contenant les composés de la présente invention, et des procédés d'inhibition de la farnésyl-protéine transférase ainsi que la farnélysation de la protéine d'oncogène Ras.

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