Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2250587

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

La présente invention concerne des composés inhibiteurs de la farnésyle-protéine transférase (FTase), ainsi que la farnésylation de la protéine oncogène Ras. L'invention concerne aussi des compositions chimiothérapeutiques qui renferment les composés de la présente invention, les méthodes permettant d'inhiber la farnésyl-protéine transférase, et la farnésylation de la protéine oncogène Ras.

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