Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 207/04 (2006.01) C07D 213/57 (2006.01) C07D 233/04 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 233/70 (2006.01) C07D 263/32 (2006.01) C07D 277/30 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06

Patent

CA 2249615

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

Cette invention a trait à des composés inhibant la farnésyl-protéine transférase (FTase) et la farnélysation de la protéine oncogène Ras. Cette invention a trait, de surcroît, à des compositions à usage chimiothérapeutique contenant les composés selon cette invention ainsi qu'à des procédés visant à inhiber la farnésyl-protéine transférase et la farnélysation de la protéine oncogène Ras.

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