Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 223/06 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01)

Patent

CA 2201347

The present invention comprises dipeptide analogs that inhibit the farnesylation of Ras. These farnesyl-protein transferase inhibitors are characterized by the inclusion of a cyclic amine in the backbone of the dipeptide. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production.

La présente invention concerne des analogues de dipeptides inhibiteurs de la farnésylation du Ras. Ces inhibiteurs de la farnésyl-transférase protéique sont caractérisés par l'inclusion d'une amine cyclique dans le squelette du dipeptide. L'invention concerne également des compositions chimiothérapeutiques à base de ces inhibiteurs de la farnésyl-transférase protéique et leurs procédés de production.

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