Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

C

C07C 57/13 (2006.01) A61K 31/19 (2006.01) A61K 31/225 (2006.01) C07C 69/52 (2006.01) C07C 69/65 (2006.01)

Patent

CA 2085283

133/MRD85 18629 TITLE OF THE INVENTION INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ABSTRACT OF THE DISCLOSURE The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemothera- peutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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