Inhibitors of fatty acid amide hydrolase

Details Inhibitors of fatty acid amide hydrolase Inhibitors of fatty acid amide hydrolase

C - Chemistry, Metallurgy

07

D

C07D 215/16 (2006.01) A61K 31/17 (2006.01) A61K 31/27 (2006.01) A61K 31/47 (2006.01) C07C 271/40 (2006.01) C07C 275/38 (2006.01) C07D 209/08 (2006.01) C07D 217/10 (2006.01) C07D 263/56 (2006.01) C07D 277/64 (2006.01) C07D 307/52 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2635232

Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.

La présente invention concerne l~inhibition pharmacologique de l~amide hydrolase d~acides gras (FAAH), qui conduit à un taux accru d~amides d~acides gras. La présente invention a trait à des esters d~acides alkylcarbamiques, qui inhibent l~activité de la FAAH. Les composés selon la présente invention inhibent l~activité de la FAAH. L~invention a également trait à des procédés permettant la préparation d~esters de composés d~acide alkylcarbamique, à des compositions incluant ces composés et à des procédés d~utilisation de ces composés.

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