Inhibitors of fatty acid amide hydrolase

Details Inhibitors of fatty acid amide hydrolase Inhibitors of fatty acid amide hydrolase

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/69 (2006.01)

Patent

CA 2757622

Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3, R4, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.

La présente invention concerne des composés de formule (I) ou leurs sels, solvates ou promédicaments pharmaceutiquement acceptables, ou des mélanges de ceux-ci, dans laquelle Z1, Z2, X1, X2, X3, R1, R2, R3, R4, m et n sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiquement acceptables comportant un composé de formule I et un excipient pharmaceutiquement acceptable. L'invention concerne en outre des procédés pour le traitement de troubles liés à l'amide hydrolase de l'acide gras (FAAH) comprenant l'administration à un sujet qui en a besoin d'une quantité thérapeutiquement efficace d'un composé ou d'une composition selon la présente invention.

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