Inhibitors of fatty acid binding protein (fabp)

Details Inhibitors of fatty acid binding protein (fabp) Inhibitors of fatty acid binding protein (fabp)

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2743299

The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein ("FABP") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I)

La présente invention porte sur de nouveaux composés hétérocycliques en tant qu'inhibiteurs de protéine de liaison aux acides gras [« FABP »], sur des compositions pharmaceutiques comprenant les composés hétérocycliques, et sur l'utilisation des composés pour traiter ou prévenir une maladie cardiovasculaire, un trouble métabolique, l'obésité ou un trouble lié à l'obésité, le diabète, une dyslipidémie, une complication diabétique, une diminution de la tolérance au glucose ou une diminution de la tolérance au glucose à jeun. Un composé illustratif de la présente invention est représenté ci-après : (I).

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