A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/34 (2006.01) A01N 43/08 (2006.01) A01N 43/20 (2006.01) A61K 31/335 (2006.01)
Patent
CA 2181031
Fatty acid synthase (FAS) is overexpressed by certain infectious organisms that are resistant to most currently available antibiotics. Contrarywise, little FAS expression is identified in patient tissues. Inhibition of fatty acid synthesis is thus selectively toxic to invasive cells, while patient cells with low FAS activity are resistant. This invention provides a method of treating septic patients where fatty acid synthesis by invading cells is inhibited with resultant interruption of the disease process.
La synthase d'acides gras (FAS) est surexprimée par certains organismes infectieux résistants à la plupart des antibiotiques actuellement disponibles. Par contre, on note une faible expression de FAS dans les tissus du patient. L'inhibition de la synthèse d'acides gras présente donc une toxicité sélective vis à vis des cellules envahisseuses, tandis que les cellules du patient à faible activité FAS s'avèrent résistantes. Cette invention constitue une méthode de traitement de patients septiques chez qui l'inhibition de la synthèse d'acides gras par les cellules envahisseuses se traduit par une interruption du processus morbide.
Dick James D.
Kuhajda Francis P.
Sim & Mcburney
The Johns Hopkins University
LandOfFree
Inhibitors of fatty acid synthesis as antimicrobial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of fatty acid synthesis as antimicrobial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of fatty acid synthesis as antimicrobial agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1756441