Inhibitors of fibroblast activation protein alpha

Details Inhibitors of fibroblast activation protein alpha Inhibitors of fibroblast activation protein alpha

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/195 (2006.01) A61K 31/69 (2006.01)

Patent

CA 2613795

Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic utilities, the peptide-based compounds may be useful for the treatment of cancer.

Cette invention concerne des composés à base de peptides qui comprennent de l'acide boronique ou une fonctionnalité cyano et qui inhibent efficacement et sélectivement la protéine alpha d'activation des fibroblastes. Parmi les utilisations thérapeutiques des composés à base de peptides figure notamment le traitement du cancer.

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